T Cell Differentiation and Function

The video explores CD4+ T cell development, activation, and differentiation into various subtypes, including Th1, Th2, Th9, Th17, Tregs, and Tfh cells. It discusses the roles of these cells in immune responses, their cytokine profiles, and the transcription factors involved in their differentiation. The concept of T cell plasticity and its implications for immune function is also covered.

What is the primary role of CD4+ T cells in the immune system?

• To provide immune protection against pathogens

• To act as antigen-presenting cells

• To produce antibodies directly

• To destroy infected host cells

Which cytokines are crucial for the differentiation of Th1 cells?

• IL-4 and IL-2

• IL-12 and IFN-γ

• IL-6 and IL-21

• TGF-β and IL-10

What is the main function of Th2 cells?

• To eliminate intracellular pathogens

• To mount immune responses to extracellular parasites

• To regulate B cell proliferation

• To suppress autoreactive responses

Which transcription factor is key in Th9 cell development?

• STAT3

• PU.1

• GATA3

• T-bet

What is the master regulator for Th17 cell differentiation?

• Bcl6

• RORγt

• FOXP3

• GATA3

Which cytokines are involved in the stabilization stage of Th17 differentiation?

• IL-23

• IL-4

• IFN-γ

• IL-12

What is the primary function of Tregs in the immune system?

• To assist in antibody production

• To produce cytokines for inflammation

• To suppress autoreactive responses and maintain self-tolerance

• To activate macrophages

Which cells are involved in the development of antigen-specific B-cell immunity?

• Tfh cells

• Th17 cells

• Th2 cells

• Th1 cells

What is a unique feature of T cell differentiation?

• It only occurs in the thymus

• It exhibits plasticity

• It is irreversible

• It is independent of cytokines

Which T cell subset is known for its role in tumor immunity?

• Th9 cells

• Th2 cells

• Th1 cells

• Tregs