Biosignaling - Janus Kinases The JAK-STAT Pathway

The video tutorial explains the JAK-STAT signaling pathway, focusing on Janus kinase (JAK) and STAT proteins. It describes how JAKs auto-phosphorylate and activate STAT proteins, which then dimerize and translocate to the nucleus to regulate gene expression. The tutorial highlights the pathway's role in immunological functions and erythropoietin signaling, emphasizing the importance of nuclear localization sequences (NLS) for nuclear entry.

What role does Erythropoietin (EPO) play in the Jack Stat pathway?

Explain the function of the nuclear localization sequence (NLS) in the Jack Stat pathway.