Apoptosis | The Extrinsic Pathway

The video tutorial by Kevin Tolkoff explores the intrinsic and extrinsic pathways of apoptosis. It begins with a recap of the mitochondrial (intrinsic) pathway, highlighting the role of mitochondria in apoptosis. The focus then shifts to the extrinsic pathway, which requires external stimuli, often from immune cells. The video details the role of caspases, particularly caspase 8 and 3, in executing apoptosis. It also discusses the crosstalk between the extrinsic and mitochondrial pathways, emphasizing how proteins like bid facilitate this interaction, leading to complete cell death.

What triggers the activation of the extrinsic pathway of apoptosis?

What are the consequences of caspase 3 activation during apoptosis?

Discuss the role of IAP (inhibitor of apoptosis) in healthy cells versus cancerous cells.

How does the protein Bid contribute to the crosstalk between the extrinsic and intrinsic pathways?