CYP2E1 Mechanism: Oxidation of Ethanol to Acetaldehyde

The video explores the metabolic pathways of ethanol, focusing on its oxidation to acetaldehyde via cytochrome P-450 enzymes. It explains the role of these enzymes in detoxifying foreign compounds and provides a detailed mechanism of ethanol conversion. The video concludes with a preview of future topics on acetaldehyde metabolism.

What is the primary enzyme responsible for converting ethanol into acetaldehyde?

Describe the role of cytochrome P-450 enzymes in the metabolism of ethanol.

Explain the significance of the CYP designation in cytochrome P-450 enzymes.

What happens to ethanol when it is metabolized by the P-450 enzyme?

Discuss the general mechanism by which P-450 enzymes detoxify foreign compounds.

What are the potential toxic effects of ethanol and its degradation products?

What is the role of cytochrome P-450 reductase in the function of P-450 enzymes?

How does the structure of heme contribute to the function of P-450 enzymes?

Describe the process of hydrogen abstraction in the conversion of ethanol to acetaldehyde.

What is the final product of the metabolism of ethanol by P-450 enzymes?