Wnt/β-Catenin Signaling Pathway | Overview, Purpose and APC Mutations

The video provides an overview of the WNT signaling pathway, explaining its role in growth and development, and its regulation through beta catenin degradation. It discusses the pathway's activation, the role of TCF in gene expression, and the impact of mutations, particularly in the APC gene, on cancer development. The video concludes with a summary of the pathway's importance in cellular processes and cancer pathogenesis.

What are the main functions of the WNT signaling pathway?

Explain the role of beta catenin in the WNT signaling pathway.

What happens to beta catenin levels in the inactivated state of the WNT signaling pathway?

Describe the process that leads to the degradation of beta catenin.

How does the activation of the WNT signaling pathway affect gene transcription?

What is the significance of mutations in the APC gene concerning the WNT signaling pathway?

In what ways can issues in the WNT signaling pathway contribute to cancer development?