Corrin/B12 Biochemistry: Methylmalonyl-S-CoA Mutase Mechanism

The video explains the beta oxidation of odd-chain fatty acids, focusing on the conversion of propionyl CoA to succinyl CoA through a short catabolic pathway. It highlights the role of adenosylcobalamin, a derivative of vitamin B12, in the methylmalonyl CoA mutase reaction. The mechanism involves radical formation and hydrogen abstraction, ultimately leading to the production of succinyl CoA, which enters the TCA cycle. The video is part of a series on fat oxidation and B12 biochemistry.

What happens to a fatty acid with an odd number of carbons during beta oxidation?

Describe the process that occurs when propionyl CoA is formed from a fatty acid.

What is the mechanism by which cobalt is involved in the reaction of methylmalonyl CoA mutase?

What is the role of adenosylcobalamin in the reaction involving methylmalonyl CoA?

Explain the significance of the term 'mutase' in the context of methylmalonyl CoA metabolism.

How does the structure of deoxyadenosine differ from normal adenosine?

Describe the role of radical formation in the mechanism of methylmalonyl CoA mutase.

How does the mechanism of methylmalonyl CoA mutase illustrate the concept of electron transfer?

What is the final product of the methylmalonyl CoA mutase reaction and its significance in metabolism?

What is the importance of vitamin B12 in the context of methylmalonyl CoA metabolism?