Biosignaling - Sonic Hedgehog (Shh) Signaling Pathway

The video tutorial explains the Hedgehog signaling pathway, crucial in developmental biology, particularly during fetal and embryonic development. It focuses on the Sonic hedgehog protein, part of a family that includes Indian and Desert hedgehog. The tutorial details the pathway's function, emphasizing the inhibition of inhibition mechanism, where the presence of Hedgehog inhibits the patched protein, allowing smoothened to activate Glee proteins, leading to gene transcription. The process involves the maturation and secretion of Hedgehog proteins, highlighting the role of dispatched in secretion and the importance of cilia in smoothened activation.

How do Glee 2 and Glee 3A contribute to the activation of Glee 1?

What is the overall effect of Hedgehog signaling on target genes?

Discuss the concept of 'inhibition of inhibition' in the context of Hedgehog signaling.