Prions | Mechanism of Kuru & Relation to Creutzfeldt-Jakob Disease

The video discusses kuru, a prion disease similar to Creutzfeldt-Jakob Disease (CJD), but transmitted through cannibalism. It explains the role of prion proteins, their misfolding, and how kuru spreads in Papua New Guinea. The disease primarily affects the cerebellum, leading to severe neurological symptoms and eventual death. Public health efforts have significantly reduced kuru cases by educating the population about the dangers of consuming infected brains.

What are the similarities between kuru and classical Creutzfeldt-Jakob Disease (CJD)?

Explain the intrinsic misfolding of the prion protein in classical CJD.

How does kuru require an extraneous source of misfolded prion protein?

Describe the process of how prion proteins aggregate in kuru.

What role does cannibalism play in the transmission of kuru?

How does the cerebellum get affected in individuals with kuru?

What neurological deficits are associated with kuru?

What are the ultimate causes of death in individuals suffering from kuru?

Discuss the historical context of kuru and its recognition as a health concern.

What measures have been taken to reduce the incidence of kuru in Papua New Guinea?