Paroxysmal Nocturnal Hemoglobinuria (PNH) | Causes & Pathogenesis, Symptoms, Diagnosis & Treatment

The video tutorial explains paroxysmal nocturnal hemoglobinuria (PNH), a rare acquired blood disorder affecting hematopoietic stem cells due to a piga gene mutation. It covers the pathophysiology involving complement activation leading to hemolysis, clinical features like hemoglobinuria and anemia, and complications such as thrombosis. Diagnosis is primarily through flow cytometry, and treatment includes eculizumab and anticoagulation. The tutorial also highlights the risk of PNH transforming into other blood disorders.

What is paroxysmal nocturnal hemoglobinuria (PNH) and how does it affect blood cells?

Explain the role of the PIGA gene in the development of PNH.

Describe the epidemiology of PNH, including its prevalence and associated risk factors.

What are the clinical features associated with PNH?

Discuss the potential complications and transformations associated with PNH.

How is PNH diagnosed and what tests are used to confirm the condition?

What treatment options are available for patients diagnosed with PNH?