Regulation of Glycogen Metabolism

The video tutorial explains the control of glycogen metabolism, focusing on the enzymes glycogen phosphorylase and glycogen synthase. Glycogen phosphorylase is activated by phosphorylation through phosphorylase kinase, which is stimulated by glucagon and epinephrine. In contrast, glycogen synthase is activated by dephosphorylation, promoted by insulin. The tutorial highlights the opposing regulation mechanisms of these enzymes, emphasizing the role of kinases and phosphatases in their activity.

What signaling molecules activate phosphorylase kinase, and how do they do it?

Describe the opposing actions of glucagon and insulin in glycogen metabolism.