Lysine Catabolism to Glutaryl-S-CoA

The video tutorial explains lysine catabolism in mammals, highlighting its convergence with tryptophan catabolism through the production of alpha keto adipate. It details the role of enzymes like lysine alpha ketoglutarate reductase and saccharopine dehydrogenase in the pathway, emphasizing the unique consumption of NADPH. The tutorial also covers the function of alpha amino adipate 6-semialdehyde dehydrogenase, which is expressed in multiple cell compartments. The process ultimately leads to the production of acetyl CoA, classifying lysine as a purely ketogenic amino acid, alongside leucine.

What is the significance of Alpha Keto Adipate in lysine catabolism?

Explain how lysine catabolism converges with tryptophan catabolism.

What role does the enzyme lysine Alpha ketoglutarate reductase play in the catabolic pathway?

Discuss the importance of NADPH in the lysine catabolic pathway.

Describe the process of how saccharin is formed in lysine catabolism.

What is the function of Alpha amino adipate 6 semi aldehyde dehydrogenase?

How does the expression of Alpha amino adipate 6 semi aldehyde dehydrogenase differ from other enzymes in the pathway?

Explain the role of transaminases in the conversion of Alpha amino adipate.

What distinguishes lysine and leucine as purely ketogenic amino acids?

What is the final product of lysine catabolism and its significance?