The Birth of Epigenetics: the Agouti Mouse Study

In 2003, Professors Randy Jirtle and Rob Waterland conducted a groundbreaking study at Duke University on agouti mice, revealing that identical genotypes can result in different phenotypes due to gene expression changes. The study showed that a transposon near the agouti gene caused obesity and yellow fur in mice. By altering the diet of pregnant mice, the researchers demonstrated that environmental factors could change gene expression, leading to healthier offspring. This study was pivotal in the field of epigenetics, challenging long-held beliefs about inheritance and disease susceptibility.

What was the main focus of the experiment conducted by Professors Randy Jirtle and Rob Waterland in 2003?

How did the agouti gene affect the appearance of the mice in the study?

What role did the transposon play in the characteristics of the yellow mice?

What dietary changes were made to the experimental group of mothers in the study?

What were the results of the experiment regarding the offspring of the mothers on a methyl-rich diet?

How did the findings of this study challenge previous scientific beliefs about genetics?

What impact did the study have on the understanding of epigenetics in relation to adult disease susceptibility?