Amyotrophic Lateral Sclerosis [ALS] | Mechanism of Neuron Death

The video discusses amyotrophic lateral sclerosis (ALS), focusing on the biochemical mechanisms leading to neuron death. It explains how protein aggregates, known as inclusion bodies, form due to genetic mutations or environmental triggers. These aggregates can act like prions, spreading from cell to cell, causing oxidative stress and neuron death. The video also covers glutamate-mediated excitotoxicity, where mutant transport proteins lead to excessive calcium influx, resulting in neuron death. Additionally, it highlights the inflammatory response triggered by prions, which further damages neurons, leading to paralysis.

How do environmental triggers relate to the onset of ALS?

What is the impact of excessive calcium levels in motor neurons?

Discuss the role of glial cells in the pathology of ALS.

What are the observable effects of ALS on skeletal muscle function?