Insulin Signaling Cascade and Downstream Effects - Biochemistry Lesson

The video explains the insulin signaling cascade, starting with insulin production in the pancreas and its role in regulating blood glucose levels. It details the structure and activation of insulin receptors, the involvement of IRS and PI3K in the signaling pathway, and the formation of PIP3 leading to AKT activation. The process of glucose transport into cells and glycogen synthesis is covered, along with the activation of mTORC1 and feedback inhibition mechanisms. The video concludes with the effects of insulin dislodgement on glucose transport.

What role does PDK1 play in the insulin signaling pathway?

How does AKT affect glycogen synthesis?

Discuss the negative feedback mechanisms involved in insulin signaling.

What happens to GLUT4 when insulin is no longer present?