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Pfizer's CEO announced that a booster dose of their COVID-19 vaccine might be needed within a year of full vaccination, with annual revaccination likely. Variants play a crucial role in this decision. The vaccine remains effective six months after the second dose. A survey shows 21% of American adults are unwilling to get vaccinated, a slight decrease from earlier surveys. Some prefer to wait and see how others respond to the vaccine. The report concludes with acknowledgments to Kaiser Health News and a look at health headlines.

What is the significance of the variants in relation to COVID vaccination, as mentioned in the text?

What reasons do some Americans have for hesitating to get the COVID vaccine?