Covalent Regulation of Glutamine Synthetase

The video explains the covalent regulation of glutamine synthetase, an enzyme that converts glutamate to glutamine. This regulation is crucial due to the enzyme's interaction with toxic ammonia. The enzyme is regulated by adenylation and deadenylation, controlled by adenyl transferase and uridyl transferase. High energy states activate glutamine synthetase, promoting biosynthesis, while low energy states favor catabolism. The video also highlights the role of P2 protein in this regulatory mechanism.

What is the primary function of glutamine synthetase?

Describe the process by which glutamine synthetase converts glutamate to glutamine.

What role does ATP play in the function of glutamine synthetase?

Explain the significance of ammonia in the regulation of glutamine synthetase.

What are the two main ways glutamine synthetase is regulated?

How does the presence of adenosine monophosphate (AMP) affect glutamine synthetase activity?

What is the relationship between uridyl transferase and the activation of glutamine synthetase?