Robertsonian Translocations & Correlation to Down Syndrome

The video discusses Down syndrome, primarily caused by nondisjunction events, and less commonly by robertsonian translocations. It explains the genetic mechanisms, including chromosome anatomy and the role of acrosomal chromosomes. The video highlights that while nondisjunction is the main cause, robertsonian translocations are clinically relevant. The mechanism of Down syndrome remains an active research area.

Discuss the significance of the P and Q arms of acrosomal chromosomes in the context of robertsonian translocations.

Why is the mechanism of Down syndrome not well understood despite knowing it involves three copies of chromosome 21?

What is the relationship between chromosome 21 and the symptoms of Down syndrome?