Nucleotide Metabolism | Basics of Thymine Biosynthesis

The video tutorial explores the biosynthetic pathways for pyrimidine nucleotides, focusing on the conversion of deoxy UMP to deoxy TMP via thymidylate synthase. It highlights the role of folate in this process and discusses enzyme inhibition strategies for cancer treatment, including the use of methotrexate and fluoro deoxy UMP as inhibitors. The tutorial emphasizes the importance of these pathways in DNA replication and cancer therapy.

What are the key differences between UMP and deoxy UMP in nucleotide metabolism?

What is the relationship between the structure of uracil and thymine in the context of nucleotide synthesis?

Identify the steps involved in converting dump to D TMP.

Discuss the mechanism by which fluoro deoxy UMP acts as a suicide inhibitor of thymidylate synthase.