Biosignaling - Receptor Tyrosine Kinases & Insulin

The video explains the receptor tyrosine kinase (RTK) pathway, focusing on insulin signaling. It describes how insulin binds to RTK, causing dimerization and activation through auto-phosphorylation. The pathway involves a series of proteins, including IRS-1, GRB2, SOS, and RAF1, leading to gene transcription. The video also discusses the role of RTKs in growth factor signaling and the potential for mutations in this pathway to cause cancer.

What is the function of the transcription factor Elk-1 in the context of insulin signaling?

How does insulin promote the synthesis of GLUT4 receptors in muscle membranes?

Explain the concept of dimerization in receptor tyrosine kinases.

Discuss the potential consequences of mutations in the proteins involved in the insulin signaling pathway.