Chaperone-Mediated Autophagy (CMA) | Selection, Mechanism and Regulation

The video explains chaperone-mediated autophagy (CMA), a selective degradation process targeting proteins with a KFRQ sequence. CMA is activated during prolonged fasting and decreases with aging and certain diets. It involves chaperone proteins like HSC70 and lysosomal proteins such as lamp2A. The process is crucial for cellular health, and its dysfunction is linked to diseases like Danon disease. Lamp2C plays a role in RNA/DNA degradation independently of HSC70. The video concludes with the importance of CMA in maintaining proteostasis.

Describe the KFR Q consensus sequence and its significance in CMA.

How does aging affect CMA function?

What are the effects of the Western diet on CMA function?

What are the implications of a decreased CMA function in relation to diseases?

What is the role of chaperones in chaperone mediated autophagy?

Discuss the role of HSC70 in the chaperone complex.

What is the function of the lysosomal membrane protein LAMP-2A in CMA?

Explain the process of how a soluble protein is targeted for degradation in CMA.

What is Danon disease and how is it related to LAMP-2A?

How does oxidative stress influence CMA function?