Glucose-6-Phosphate Dehydrogenase Deficiency | Symptoms, Pathophysiology, Diagnosis and Treatment

The video tutorial explains glucose 6 phosphate dehydrogenase (G6PD) deficiency, the most common enzymatic deficiency in red blood cells. It covers the prevalence, pathophysiology, and classification of the condition based on enzyme activity. The tutorial also discusses clinical presentations, triggers for acute hemolysis, and methods for diagnosis and management, including avoiding certain medications and foods.

What is the most common enzymatic deficiency in red blood cells?

• Glucose 6 phosphate dehydrogenase deficiency

• Lactase deficiency

• Hexokinase deficiency

• Aldolase deficiency

How is glucose 6 phosphate dehydrogenase deficiency inherited?

• X-linked recessive

• Y-linked

• Autosomal recessive

• Autosomal dominant

What is the primary role of NADPH in red blood cells?

• To generate ATP

• To synthesize hemoglobin

• To transport oxygen

• To reduce reactive oxygen species

Which class of glucose 6 phosphate dehydrogenase deficiency is the most severe?

• Class 1

• Class 2

• Class 3

• Class 4

What type of anemia is commonly seen in glucose 6 phosphate dehydrogenase deficiency?

• Sideroblastic anemia

• Normochromic normocytic anemia

• Megaloblastic anemia

• Microcytic anemia

What are 'bite cells' indicative of in a blood smear?

• Thalassemia

• Glucose 6 phosphate dehydrogenase deficiency

• Sickle cell anemia

• Iron deficiency anemia

Which food is known to trigger acute hemolysis in glucose 6 phosphate dehydrogenase deficiency?

• Spinach

• Broccoli

• Carrots

• Fava beans

Which medication is NOT a known trigger for acute hemolysis in glucose 6 phosphate dehydrogenase deficiency?

• Dapsone

• Primaquine

• Nitrofurantoin

• Aspirin

What is the most reliable screening test for glucose 6 phosphate dehydrogenase deficiency?

• Complete blood count

• Fluorescent spot test

• Urinalysis

• Liver function test

What is a common management strategy for glucose 6 phosphate dehydrogenase deficiency?

• Increasing iron intake

• Daily aspirin

• Avoiding known triggers

• Regular blood transfusions