Mechanisms of Oxygen Dissociation from Hemoglobin

The video explains how oxygen is transported in the blood via hemoglobin and how metabolically active cells can enhance oxygen dissociation to meet their increased demand. It covers the effects of heat, carbon dioxide, hydrogen ions, and 2,3-Bisphosphoglycerate (2,3-BPG) on oxygen release from hemoglobin, highlighting the Haldane and Bohr effects.

What is the primary role of hemoglobin in the blood?

• To transport carbon dioxide

• To bind and transport oxygen

• To regulate blood pressure

• To carry nutrients

How does increased blood temperature affect oxygen dissociation from hemoglobin?

• It strengthens the bond between oxygen and hemoglobin

• It causes hemoglobin to denature

• It has no effect on oxygen dissociation

• It weakens the bond, facilitating oxygen release

What is the Haldane effect primarily associated with?

• The binding of carbon dioxide to hemoglobin

• The binding of oxygen to hemoglobin

• The production of ATP

• The release of heat from cells

Which amino acid on hemoglobin is involved in the Haldane effect?

• Serine

• Lysine

• Alanine

• Glycine

What effect do hydrogen ions have on the interaction between hemoglobin and oxygen?

• They strengthen the interaction

• They have no effect

• They weaken the interaction, promoting oxygen release

• They cause hemoglobin to bind more carbon dioxide

What is the role of 2,3-Bisphosphoglycerate in oxygen dissociation?

• It strengthens the bond between oxygen and hemoglobin

• It facilitates the release of oxygen from hemoglobin

• It converts oxygen into carbon dioxide

• It prevents oxygen from binding to hemoglobin

How do metabolically active cells signal the need for more oxygen?

• By releasing hydrogen ions

• By decreasing blood temperature

• By producing more hemoglobin

• By reducing carbon dioxide levels