The Inflammatory Response

The video explains the inflammatory response, focusing on acute inflammation, its signs, and roles. It details the vascular and cellular components, protein cascades like the kinin and coagulation systems, and endothelial activation. The resolution phase is discussed, highlighting the importance of balance to prevent chronic inflammation.

Which of the following is NOT a classical sign of inflammation described by Celsus?

• Pain

• Redness

• Swelling

• Fever

What is the primary role of acute inflammation?

• To contain and eliminate pathogens

• To spread infection

• To increase body temperature

• To cause chronic diseases

What is the first step in the inflammatory response?

• Increase in body temperature

• Release of antibodies

• Formation of blood clots

• Sensing of tissue damage or microbial infection

Which of the following is a product of the kinin system?

• Histamine

• Bradykinin

• Prostaglandin

• Leukotriene

What is the role of the coagulation system in inflammation?

• To increase blood flow

• To trap pathogens in fibrin clots

• To decrease vascular permeability

• To promote pain sensing

Which protein on endothelial cells helps immune cells adhere during inflammation?

• Myosin

• Hemoglobin

• Albumin

• ICAM-1

What process allows immune cells to move between endothelial cells into tissue?

• Chemotaxis

• Extravasation

• Phagocytosis

• Opsonization

What is the role of neutrophils in the resolution of inflammation?

• They release pro-inflammatory cytokines

• They increase vascular permeability

• They undergo apoptosis and are cleared by macrophages

• They promote chronic inflammation

Which lipid mediator is involved in the resolution of inflammation?

• Leukotriene

• Histamine

• Prostaglandin

• Resolvin

What can result from a failure to resolve inflammation?

• Enhanced tissue repair

• Increased pathogen clearance

• Chronic inflammation

• Improved immune response