Biginelli Reaction

Biginelli Reaction

Assessment

Interactive Video

Biology, Chemistry, Physics, Science

11th Grade - University

Hard

Created by

Quizizz Content

FREE Resource

The video tutorial covers the Biginelli reaction, a multicomponent reaction involving an aromatic aldehyde, urea, and a beta keto ester to produce dihydropyrimidinone. It discusses the reaction's history, mechanism, and its significance in creating chemical libraries for biological screening. The tutorial also explores the structure and nomenclature of pyrimidines, the reaction's mechanism, and the development of enantioselective versions using chiral acids. The Biginelli reaction's applications in modern organic synthesis are highlighted, demonstrating its enduring relevance.

Read more

7 questions

Show all answers

1.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Who discovered the Biginelli reaction and in which year?

Marie Curie in 1911

Isaac Newton in 1687

Albert Einstein in 1905

Pietro Biginelli in 1891

2.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the main product of the Biginelli reaction?

Dihydropyrimidinone

Benzene

Methane

Ethanol

3.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

In the Biginelli reaction product, which positions are hydrogen atoms added to?

Positions 1 and 2

Positions 3 and 4

Positions 7 and 8

Positions 5 and 6

4.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the first step in the proposed mechanism of the Biginelli reaction?

Formation of a hemiaminal

Formation of a carbocation

Formation of a radical

Formation of a ketone

5.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which intermediate is formed during the Biginelli reaction mechanism?

Radical

Carbocation

Ketone

Carbomoil iminium ion

6.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What type of catalyst did Professor Liu Xu Gong use in his research on the Biginelli reaction?

Nitric acid

Chiral phosphoric acid

Sulfuric acid

Hydrochloric acid

7.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the enantiomeric excess achieved by Professor Liu Xu Gong in his study of the Biginelli reaction?

75%

50%

97%

100%