Bradykinin Storms and Covid Inflammation

The video explores the concept of 'bradykinin storm' as a potential cause of severe inflammation in COVID-19 patients, contrasting it with the more familiar 'cytokine storm'. It discusses how the virus may increase bradykinin levels, leading to inflammation and tissue injury. The video also highlights research suggesting that certain populations may be more sensitive to bradykinin, potentially explaining higher mortality rates. It concludes with a discussion on potential treatments and ongoing clinical trials to test the bradykinin hypothesis.

What is the primary role of cytokines in the immune system?

• To destroy infected cells directly

• To regulate immune responses

• To secrete antibodies

• To cause inflammation and fatigue

What is the hypothesized effect of SARS-CoV-2 on ACE2 receptors?

• It increases ACE2 expression

• It reduces ACE2 expression

• It has no effect on ACE2 expression

• It blocks ACE2 receptors completely

How does the increase in bradykinin levels affect the body during a COVID-19 infection?

• It reduces inflammation

• It enhances the immune response

• It causes a decrease in Dabc levels

• It leads to increased inflammation and tissue injury

What is Icatibant primarily used to treat?

• Hereditary angioedema

• Common cold

• Asthma

• Influenza

What is the current status of the research on Icatibant for COVID-19 treatment?

• It has been approved by the FDA for COVID-19

• It is still in the hypothesis testing phase

• It is widely used in clinical practice

• It has been proven ineffective