Metabolism of Adipate & Adipyl-CoA

The video tutorial explains the similarities between adipate and atypical COA molecules, focusing on their roles in fatty acid oxidation pathways, particularly Omega oxidation. It details the enzymatic reactions involved in the breakdown of these molecules, leading to energy production through the TCA cycle. The tutorial also highlights the conversion of these molecules into acetyl CoA and succinyl CoA, emphasizing their importance in cellular energy metabolism.

What is the primary structural difference between adipate and atypical CoA?

• Atypical CoA has a coenzyme A ligated to one of its carboxyl groups.

• Atypical CoA lacks a carboxyl group.

• Adipate is a longer chain molecule.

• Adipate has an extra hydroxyl group.

Which fatty acid undergoes Omega oxidation in the discussed pathway?

• Oleic acid

• Lauric acid

• Stearic acid

• Palmitic acid

What is the role of atypical CoA dehydrogenase in the oxidation process?

• It removes a carboxyl group from the molecule.

• It inserts a double bond between the alpha and beta carbon.

• It splits the molecule into two smaller fragments.

• It adds a hydroxyl group to the molecule.

Which enzyme is responsible for adding a hydroxyl group across the double bond in atypical CoA?

• Atypical CoA dehydrogenase

• Citrate synthase

• Enoyl-CoA hydratase

• Thiolase

What are the final products of the atypical CoA oxidation process?

• Citrate and isocitrate

• Malonyl CoA and succinate

• Fumarate and oxaloacetate

• Acetyl CoA and succinyl CoA

Into which cycle do acetyl CoA and succinyl CoA enter after their formation?

• Citric acid cycle

• Urea cycle

• Glycolysis

• Pentose phosphate pathway

Which enzyme catalyzes the first step of the citric acid cycle?

• Aconitase

• Citrate synthase

• Isocitrate dehydrogenase

• Succinyl CoA synthetase