Mannich Reaction
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Chemistry, Science
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11th Grade - University
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Hard
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7 questions
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1.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Who invented the Mannich Reaction?
Albert Eschenmoser
Emil Fischer
Friedrich Wohler
Carl Mannich
2.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What are the three components involved in the Mannich Reaction?
Aldehyde, a primary amine, and a ketone
Formaldehyde, a primary amine, and an ester
Formaldehyde, an enolizable ketone, and a secondary amine
Ketone, a tertiary amine, and water
3.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What is formed when a secondary amine reacts with formaldehyde in the Mannich Reaction?
Iminium ion
Aldol
Carbanion
Enolate
4.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What is a key application of the Mannich Reaction?
Formation of alpha methylene ketones
Creation of carboxylic acids
Synthesis of alcohols
Production of esters
5.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What are Eschenmoser salts used for in the Mannich Reaction?
To stabilize the reaction
To act as a nucleophile
To catalyze the reaction
To form iminium ions
6.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What is the role of S-proline in the advanced Mannich Reaction?
It acts as a solvent
It is a byproduct
It is a chiral catalyst
It is a reactant
7.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What is the main challenge when extending the Mannich Reaction to aldehydes other than formaldehyde?
High cost of reagents
Excessive byproducts
Lack of reactivity
Formation of multiple diastereomers
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