QUIZ Huntington's disease treatment (24/09/25)

In the opening segment, the presenter characterizes the news about Huntington’s disease treatment in what specific way, emphasizing its immediacy and significance?

• As a routine update from an annual report
• As breaking news about a just-released trial

• As a historical review of past treatments that cured Huntington's disease

• As a speculative opinion piece

According to the video, Huntington’s disease is often described as a mixture of which three conditions, highlighting its combined cognitive and motor decline?

• Dementia, Parkinson’s, and motor neuron disease
• Leukemia, epilepsy, and multiple sclerosis
• ALS, Dementia, and essential tremor

• Stroke, Parkinson, and cerebral palsy

In the UK context given by the presenter, approximately how many people are affected by Huntington’s disease, underscoring its national prevalence?

• Around 70,000 people
• Around 700 people
• Around 7,000 people
• Around 17,000 people

When discussing inheritance, what clarification does Fergus Walsh make about risk and certainty that corrects the earlier wording?

• Children have a 25% chance to inherit the gene; if inherited, there’s a 90% chance to develop the disease
• Children have a 50/50 chance to inherit the gene; if you inherit it, there’s a 100% chance you’ll develop the disease
• Children have a 75% chance to inherit the gene; development is uncertain even if inherited
• Children have a 100% chance to inherit the gene; if inherited, there’s a 50/50 chance to develop the disease

In terms of disease timeline, what typical life stage is mentioned for the onset of Huntington’s disease, as stated in the introduction?

• Middle age
• Early childhood
• Late adolescence
• Very old age

Regarding the trial’s scope and intervention, which description matches the procedure delivered to the participants according to Fergus?

• A monthly course of intravenous infusions over three years
• A twice-yearly spinal injection administered under sedation
• A one-off injection delivered into six parts deep in the brain
• A daily oral medication combined with physiotherapy

What sample size does Fergus explicitly cite when summarizing the top-line three-year data from this study?

• 92 patients
• 29 patients
• 49 patients
• 19 patients

The average slowing of Huntington’s disease progression reported over three years in this cohort was quantified how, based on the measured outcomes?

• 75% average slowing
• 35% average slowing
• 15% average slowing
• 95% average slowing

Which outcome domains are named as being part of the measures used to assess the trial’s impact on participants’ daily functioning?

• Heart rate variability, sleep duration, and blood glucose
• Lung capacity, bone density, and visual acuity
• Cognition, movement, and ability to lead an independent life
• Kidney function, liver enzymes, and skin elasticity

When reflecting on prior research attempts, how does Professor Edward Wild characterize the history of Huntington’s clinical trials before this result?

• Numerous large trials all showing strong, consistent benefits
• Many trials with incremental progress but ultimately negative outcomes
• Few trials conducted due to lack of interested participants
• Several successful drug approvals that transformed care