Q4ETNOABP6

Banaba (Lagerstroemia speciosa) leaves are traditionally used in Southeast Asia to treat which disease?

• Hypertension

• Sweet urine disease (Diabetes)

• Tuberculosis

• Malaria

Which compound is considered the identity marker of Banaba leaf extract?

• Gallic acid

• Corosolic acid

• Quercetin

• Oleanolic acid

Which triterpene acid in Banaba is widely recognized for its insulin-mimetic activity?

• Vitamin C

• Caffeine

• Corosolic acid

• Glucose

Which mechanism involves activation of the PI3K/Akt pathway and GLUT4 translocation?

• Inhibition of PTPs

• Enhancement of glucose uptake

• Inhibition of carbohydrate digestion

• Suppression of gluconeogenesis

Which systemic anti-diabetic effect is NOT associated with Banaba?

• Reduction of fasting blood glucose

• Increase of LDL cholesterol

• Increase of HDL cholesterol

• Improvement of insulin sensitivity

DLBS3233 is a standardized extract combination of which two plants?

• Cinnamomum burmannii and Lagerstroemia speciosa

• Andrographis paniculata and Zingiber officinale

• Curcuma longa and Morinda citrifolia

• Panax ginseng and Camellia sinensis

Which signaling molecules are upregulated by DLBS3233 to enhance glucose uptake?

• PPARγ and PPARδ

• ICAM-1 and TNF-α

• LDHA and LDHB

• G6Pase and PFKFB3

A 2012 phase-I study of DLBS3233 found that it…

• Caused severe hypoglycemia

• Was unsafe in healthy volunteers

• Was safe and well tolerated without liver/kidney impairment

• Showed no insulin-sensitizing effect

In women with PCOS, DLBS3233 showed an effect comparable to which drug in reducing insulin resistance?

• Pioglitazone

• Metformin

• Glibenclamide

• Sitagliptin

A 2025 cost-effectiveness analysis of DLBS3233 in Indonesia concluded that…

• It was not effective compared to placebo

• It increased overall treatment costs

• It was cost-effective, reducing total costs and improving QALYs

• It caused more adverse events than metformin