Pharmacology and Hypertension

ADME relates to pharmacokinetics and is short for

How medications travel through the body

• Pharmacokinetics

• Pharmacodynamics

• Polypharmacy

Transmission of medications from the location of the administration to the bloodstream

• Absorption

• Distribution

• Metabolism

• Excretion

______ of administration affects the rate and amount of absorption

Routes of administration and effects on absorption include

• PO

• IV

• IM

• DD

Tags

NGSS.HS-PS1-5

Medication must pass through the tissue lining of the GI tract

• Sublingual

• Buccal

• Oral

• Injections

Absorbed over long period, sustained/extended release

NOT CRUSHED OR CHEWED!

• Entric-Coated Tab

• Chewable Tab

• Immediate release
• Film Coated Tab

• Sublingual

• Buccal

• Oral

• Entric Coated

What happens when you swallow sublingual/buccal medication before it is dissolved?

• Gastric acid will inactivate the medication

• It enhances the medication's effectiveness.
• It has no effect on the medication's absorption.
• It speeds up the dissolution process.