REVIEW Do1 WEEK 3 QUIZ 2

The adverse effects that occur during corticosteroid use include all of the following, except:

• suppression of the hypothalamic-pituitary-adrenal (HPA) axis

• hypercorticism with changes in fat distribution and posterior cervical hump formation

• Hypertension, congestive heart failure, emotional changes, thinning of skin, petechiae, diabetes, Menstrual irregularities

• increased muscle mass, decreased appetite, improved bone density, or lower blood pressure,

• electrolyte imbalances, liver and pancreatic dysfunction, exophthalmos, glaucoma, loss of muscle mass, osteoporosis, muscle weakness

What is the main function of Cyclosporine?

• inhibits the synthesis of insulin in pancreatic beta cells.

• Stimulates the production of red blood cells in the bone marrow.

• Acts as a broad-spectrum antibiotic against bacterial infections.

• Reversibly suppresses T helper cells in the G0 or G1 phase of the cell cycle without killing them.

Histamine binds to H1 (histamine 1), H2, H3, and H4 receptors, which are located on many types of cells. Which white blood cell expresses predominantly H2 receptors?

• neutrophils

• Basophils

• Eosinophils

• Monocytes

The H3 receptors are located? select all that apply

• the brain

• Human skin

• in the spinal cord

• gastrointestinal tract

• on sensory neurons such as postganglionic cholinergic nerves in lung bronchi

This medication inhibits the synthesis of DNA and are used in multiple autoimmune diseases. Side effects include increased risk of malignancy, bone marrow suppression, nausea, and vomiting. Name the medication.

• Cyclophosphamide (an alkylating agent)

• Methotrexate (a folate analog)

• Azathioprine (a purine analog)

• Cyclosporine (a calcineurin inhibitor)

Therapeutic plasmapheresis has been effective in the management of following diseases, EXCEPT;

• Goodpasture's syndrome

• Myasthenia gravis

• Rheumatoid arthritis

• Guillain-Barre syndrome

Intravenous immunoglobulin (IVIg) can also be used for the following disorders, Except;

• Kawasaki disease

• Immune thrombocytopenic purpura

• Guillain-Barre syndrome

• Hypertension

This type of hypersensitivity reaction is mediated by the IgG/IgM immune complex, as in immune complex glomerulonephritis and SLE.

• Type III hypersensitivity

• Type I hypersensitivity

• Type II hypersensitivity

• Type IV hypersensitivity

This type of hypersensitivity reaction is a T cell–mediated and has all of the following categories except; Select all that apply.

• Type I: Atopic, Anaphylactic

• Type II: Cytotoxic, Cytolytic

• Type III: Immune Complex (Arthus Reaction)

• Type IV: Delayed Hypersensitivity

Which type is mediated by IgE and leads to mast cell degranulation?

• Type I: Atopic, Anaphylactic

• Type II: Cytotoxic, Antibody-dependent

• Type III: Immune Complex-mediated

• Type IV: Delayed-type, Cell-mediated