BMS I Review

Which protein modification is key to activating RNA polymerase II during transcription initiation?

• Ubiquitination

• Glycosylation

• Phosphorylation

• Acetylation

Housekeeping genes typically exhibit which of the following transcription characteristics?

• Inducible expression with variable levels

• No promoter regions

• Constitutive expression with relatively stable protein output

• Expression only during mitosis

Which component facilitates vesicle scission in clathrin-mediated endocytosis?

• Flippase

• Caveolin

• Dynamin

• Scramblase

Which lipid type contains a sphingosine backbone and determines human blood group antigens?

• Glycerophospholipids

• Sterols

• Triacylglycerols

• Sphingolipids

Which of the following would most likely lower the melting point of a fatty acid?

• Increasing carbon chain length

• Adding cis double bonds

• Removing carboxylic acid group

• Saturating the chain

Which of the following best describes the role of topoisomerase II during DNA replication and transcription?

• Adds methyl groups to cytosine residues

• Removes introns from pre-mRNA

• Resolves DNA supercoiling by breaking and rejoining double strands

• Catalyzes peptide bond formation

In eukaryotic transcription, the basal rate of transcription is most directly influenced by which factor?

• Intronic sequences

• Codon bias

• Promoter sequence and RNA polymerase interaction

• Polyadenylation signal

What drives the formation of a liposome in an aqueous solution?

• High Gibbs free energy

• Reduced entropy

• Hydrophobic effect and water release

• Ester bond formation

Which of the following regulatory proteins blocks transcription by physically preventing RNA polymerase from binding to the promoter?

• Activator

• Enhancer

• Specificity factor

• Repressor

What would be the immediate consequence of using a drug that inhibits chromatin remodeling proteins?

• Enhanced ribosome assembly

• Inhibition of transcription initiation

• Increased protein degradation

• Uncontrolled mRNA splicing