Pemphigus and Bullous Disorders Quiz

Which of the following features is characteristic of pemphigus vulgaris?

• Subepithelial blister

• Target lesions on skin

• Positive Nikolsky sign

• Minimal oral involvement

In bullous pemphigoid, the bullae form due to separation at the level of:

• Stratum corneum

• Stratum spinosum

• Lamina lucida

• Desmosomes

Which antigen is primarily targeted in mucous membrane pemphigoid?

• Desmoglein 3

• BP180

• Collagen type IV

• Keratin

Acantholysis in pemphigus vulgaris leads to the presence of:

• Civatte bodies

• Tzanck cells

• Koilocytes

• Ghost cells

A 24-year-old male presents with target skin lesions and crusted erosions on his lips. Which of the following is the most likely diagnosis?

• Herpetic stomatitis

• Erythema multiforme

• Mucous membrane pemphigoid

• Bullous lichen planus

Case:
A 48-year-old woman complains of painful blisters in her mouth for two weeks. Clinical exam reveals positive Nikolsky sign and multiple erosions in buccal mucosa. No skin involvement is observed.

Based on the presentation, what is the most likely diagnosis?

• Bullous pemphigoid

• Pemphigus vulgaris

• Erythema multiforme

• Herpes zoster

Which diagnostic test would help confirm your suspected diagnosis?

• KOH preparation

• Direct immunofluorescence

• VDRL

• Mantoux test