Tuberculosis (TB) Knowledge Assessment

Which bacterium is the causative agent of tuberculosis?

• Mycobacterium tuberculosis

• Streptococcus pneumoniae

• Escherichia coli

• Staphylococcus aureus

What is the preferred diagnostic test for latent tuberculosis infection in BCG-vaccinated individuals?

• IGRA (QuantiFERON-TB Gold)

• Skin Test (PPD)

• Chest X-ray

• Culture

Which of the following is a common symptom of active tuberculosis?

• Cough

• Rash

• Headache

• Abdominal pain

What is the main mechanism of action of Isoniazid (INH) in tuberculosis treatment?

• Inhibits mycolic acid synthesis

• Inhibits protein synthesis

• Disrupts cell wall peptidoglycan

• Blocks DNA gyrase

Which of the following is a side effect of Rifampin?

• Red/orange body fluids

• Hearing loss

• Hyperkalemia

• Photosensitivity

A 30-year-old patient with latent TB is prescribed INH and Rifapentine weekly for 3 months. What is the minimum age for this regimen?

• 12 years

• 6 years

• 18 years

• 21 years

Why is Vitamin B6 supplemented with Isoniazid (INH) therapy?

• To reduce hepatotoxicity risk

• To prevent neuropathy

• To enhance drug absorption

• To increase drug potency

Which population is at increased risk for progression to active TB

• Individuals with HIV

• Individuals with diabetes

• Individuals with hypertension

• Individuals with asthma

Explain why reactivation of tuberculosis is more likely in immunosuppressed individuals. (DoK Level 3)

• Dormant bacilli are reactivated due to weakened immune surveillance.

• The bacteria mutate to become more virulent.

• The drugs used are less effective in these individuals.

• They are more likely to be exposed to new infections.

Which of the following drugs is a fluoroquinolone used in the treatment of MDR-TB?

• Levofloxacin

• Linezolid

• Clofazimine

• Ethionamide