HIV Protease Inhibitors and Integrase Inhibitors

All protease inhibitors need to be boosted with which of the following?

• fostemavir

• ritonavir

• cobicistat

• lenacapavir

Which of the following is used in combination with other ARVs to treat HIV-1 in heavily treated adults with multidrug resistant virus?

• fostemavir

• ritonavir

• cobicistat

• lenacapavir

Which of the following is contraindicated in strong P450 3A4 inducers carbamazepine, phenytoin, rifampin, St. John’s wort, mitotane, statin therapy.

• fostemavir

• ritonavir

• cobicistat

• lenacapavir

which of the following are not considered antiretroviral agents?

• fostemavir

• ritonavir

• cobicistat

• lenacapavir

which of the following is an HIV-1 capsid inhibitor for treatment of HIV-1 infection in heavily treatment-experienced adults with multidrug resistant HIV-1

• fostemavir

• ritonavir

• cobicistat

• lenacapavir

which of the following agents is a selective CYP3A4 inhibitor as well as inhibits some CYP2DG.

• fostemavir

• ritonavir

• cobicistat

• lenacapavir

which of the following agents has minimal effect on P-gp, OATP1B1/B3.

• fostemavir

• ritonavir

• cobicistat

• lenacapavir

which of the following agents can interfere with creatinine tubular secretion and may need to be stopped if CrCL < 30-50mL/min per package insert?

• fostemavir

• ritonavir

• cobicistat

• lenacapavir

Ritonavir and cobicstat are "boosters" for which of the following classes of anti-HIV drugs?

• NRTIs

• NNRTIs

• Protease Inhibitors

• Integrase Inhibitors

Match the drug

• atazanavir

• Reyataz

• Darunavir

• Aptivus

• Tipranavir

• Prezista

• lopinavir with ritonavir

• Lexiva

• fosamprenavir

• Kaletra