Breast Cancer Quiz

What is the primary function of estrogen in breast tissue?

• To inhibit cell growth

• To decrease blood flow

• To promote cell proliferation

• To induce apoptosis

Which type of breast cancer is characterized by the absence of ER, PR, and HER2?

• Luminal A

• Luminal B

• HER2 enriched

• Triple-negative

What is the molecular weight of the full-length ERα protein?

• 66 kDa

• 80 kDa

• 60 kDa

• 70 kDa

Which domain of the estrogen receptor has activation function (AF1)?

• A/B domain

• Hinge domain

• Ligand-binding domain

• DNA-binding domain

What is the role of coactivators in estrogen receptor signaling?

• To inhibit transcription

• To enhance transcription

• To degrade the receptor

• To bind to DNA

Which of the following is a common post-translational modification of ER?

• Transcription

• Glycolysis

• Dephosphorylation

• Phosphorylation

What is the primary method for early-stage breast cancer diagnosis?

• Mammogram

• CT scan

• Breast biopsy

• Ultrasonography

What is the main characteristic of Luminal A breast cancer?

• ER+, PR-, HER2+

• ER-, PR-, HER2-

• ER+, PR+, HER2-

• ER-, PR-, HER2+

Which treatment is commonly used for node-positive breast cancer?

• Radiation therapy

• Chemotherapy

• Immunotherapy

• Surgery

What is the function of the BRCA1 gene in breast cancer?

• Enhances chemotherapy effects

• Regulates estrogen levels

• Inhibits tumor growth

• Promotes tumor growth