MP 180 B

Familly name // nom de famille

What is your team color ? // Quelle est la couleur de votre équipe ?

How many people are in the NMT team?

• 16

• 19

• 22

• 25

Which diseases the NMT team is studing in our research?

• Charcot-Marie-Tooth disease

• Dysferlinopathies

• Emery-Dreiffus muscular dystrophy

• Calpainopathies

What's the most common injury in our lab?

• Water bath burns

• Infected cells

• fractured pipettes

• mouse bites

• broken dreams

1. What gene is mutated in Imane’s study?

• PLEC1 gene

• PCL1 gene

• PLOS1 gene

• PICKELS1 gene

What model does Imane use to study muscle cells?

• Induced pluripotent stem cells differentiated into smooth muscle cells.

• Induced pluripotent stem cells differentiated into skeletal muscle cells.

• Induced totipotent stem cells differentiated into skeletal muscle cells.

• Induced pluripotent stem cells differentiated into football players.

1. What is the main problem that Imane is trying to solve?

• Understanding whether the Plectin mutation and resulting deficiency are responsible for causing muscular hypertrophy in elite bodybuilders.

• Understanding whether the Plectin mutation and resulting deficiency are responsible for causing myocardial infarctionin undiagnosed patients.

• Understanding whether the Plectin mutation and resulting deficiency are responsible for causing muscular dystrophy in undiagnosed patients.

• Understanding whether the Plectin mutation and resulting deficiency are responsible for causing muscular dystrophy in diagnosed patients.

Why do you think spatial context is important for identifying functional domains in your own research?

• Spatial context isn't really relevant

• It connects gene expression profiles to their position in the tissue, which helps reveal organized structures.

• Gene expression doesn't vary much across tissues.

• We typically ignore spatial information since it's too noisy to be useful.

2. Could jsPCA be extended to integrate other spatial data modalities?

• • No, jsPCA is strictly limited to 2D spatial gene expression and cannot be modified.

• • It can’t be used with any modality that involves imaging data.

• Yes, jsPCA can capture relevant spatial structures in a variety of contexts.

• • Any extension would require rewriting the entire algorithm from scratch.

• Why is Gamora