BIO-358 Topic 5 Quiz

When T cells leave the bone marrow and enter the thymus, they are

• double negative

• double positive

• single positive, either CD4+ or CD8+

• mature naive T cells

Double positive T cells are found in what region of the thymus

Where does positive selection of T cell occur?

• bone marrow

• Cortex of the thymus

• Medulla of the thymus

• Subcapsular region of the thymus

The purpose of negative selection is to

• delete all T cells that are still double positive

• delete T cells that interact with MHC molecules

• delete T cells that recognize self antigens

• prepare T cells for positive selection

The transcription factors, ThPOK and Runx3, promote development of

• CD8+ and CD4+ T cells

• B cell precursors

• T reg cells

• CD4+ and CD8+ T cells

The transcription factor that promotes expression of many self proteins in the thymus and is used in negative selection is

• Terminal deoxynucleotidyl transferase (TdT)

• AutoImmune REgulator (AIRE)

• ThPOK

• Runx3

The organ that filters antigens present in the blood is the

• heart

• lymph node

• spleen

• bone marrow

In lymph nodes, the cortex region contains

• T cells

• dendritic cells

• very few cells

• B cells

B and T cells enter the lymph nodes via the

• afferent lymphatics

• efferent lymphatics

• subcapsular sinus

• high endothelial venules

Specialized cells that promote formation of lymphoid tissue during fetal development are called ________ cells(use abbreviation)