MCQ: Resolution of Racemic mixtures

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What is the primary goal of resolving a racemic mixture?

• A) To separate diastereomers
• B) To obtain enantiomerically pure compounds
• C) To increase the solubility of the mixture
• D) To form a new racemic compound

A racemic mixture can be resolved using:

• A) Chiral acids or bases
• B) Achiral resolving agents
• C) Recrystallization from a nonpolar solvent
• D) Fractional distillation

Which chromatographic technique is widely used for resolving racemic mixtures?

• A) Gas chromatography
• B) Column chromatography
• C) Chiral high-performance liquid chromatography (HPLC)
• D) Thin-layer chromatography (TLC)

Enzymatic resolution of racemic mixtures occurs due to:

• A) The formation of diastereomers
• B) The difference in reactivity of enantiomers with a chiral enzyme
• C) Preferential crystallization
• D) The use of nonpolar solvents

The formation of diastereomeric salts for resolution requires:

• A) An achiral solvent
• B) A chiral resolving agent
• C) A racemic catalyst
• D) A strong acid

Which of the following is NOT a method for resolving racemic mixtures?

• A) Enzymatic hydrolysis
• B) Crystallization with a chiral resolving agent
• C) Chromatography on an achiral stationary phase
• D) Kinetic resolution

The optical purity of a resolved enantiomer is determined by:

• A) Refractive index
• B) Infrared spectroscopy
• C) Optical rotation measurement
• D) pH analysis