MEDDOP WEEK 8

The ​ (a)   unwinds the DNA double helix at replication forks. ​ (b)   then synthesizes RNA primers, which are used by ​ (c)   to synthesize new DNA strands. Finally, ​ (d)   joins the Okazaki fragments together.

• Helicase
• Primase
• DNA pol III
• DNA ligase

Categorize the following proteins based on their functions:

Groups:

(a) DNA Structure Modifiers

,

(b) DNA Synthesis Proteins

,

(c) DNA Joining Proteins

• DNA pol III

• DNA pol I

• Topoisomerase

• Helicase

• Primase

• DNA ligase

Which type of hypersensitivity reaction is characterized by immune complex-mediated response and typically has an onset of 1-3 weeks?

• Type I

• Type II

• Type III

• Type IV

Match the hypersensitivity type with its mediator:

• IgE-Mediated

• Type III

• IgG or IgM Cytotoxic

• Type I

  
  

• T-Cell-Mediated

• Type IV

• Immune Complex-Mediated

• Type II

Type ​ (a)   hypersensitivity presents with anaphylaxis, while Type​ (b)  
presents with serum sickness and SLE.

• I
• III
• II
• IV

 Which health metric is considered the best measure of cost-effectiveness of intervention?

• DALY

• QALY

• HALE

• Sullivan's Index

Arrange these scoring scales from lowest to highest value:

•  Perfect health in DALY

• Perfect health in QALY

• Death in QALY

• Death in DALY

Categorize these diseases by their HLA class:

Groups:

(a) HLA-A associated

,

(b) HLA-B associated

,

(c) HLA-D associated

• Ankylosing spondylitis

• Narcolepsy

• Multiple sclerosis

• Haemochromatosis

• Celiac disease

• Sarcoidosis

• Rheumatoid arthritis

• Behçet disease

 Which HLA type is associated with both Type 1 Diabetes Mellitus and Systemic Lupus Erythematosus?

• HLA-DR2

• HLA-DR3

• HLA-DR4

•  HLA-DR5

The enzyme _____ is responsible for breaking, swiveling, and rejoining DNA strands to relieve overwinding strain during replication.