Reading Signal Transduction Pathways

Examine the Signal Transduction pathway below and put the events in the correct order.

• Ligand binds to the receptor

• Relay Protein 1 is activated

• Relay Protein 2 is activated

• Response occurs in the cell.

Examine the Signal Transduction pathway and put the events in the correct order.

• Ligand binds to the receptor

• adenylyl cyclase converts ATP into cAMP, removing two phosphates and linking the remaining phosphate to the sugar in a ring shape.

• cAMP activates an enzyme called protein kinase A (PKA)

• Response occurs in the cell.

Examine the Signal Transduction pathway and put the events in the correct order.

• Ligand binds to the receptor

• an enzyme called phospholipase C cleaves (chops) PIP2 into two fragments, DAG and IP3

• DAG stays in the plasma membrane and activates a target called protein kinase C (PKC)

• Phosphorylation occurs

• Response occurs in the cell.

Examine the Signal Transduction pathway and put the events in the correct order.

• Ligand binds to the receptor

• an enzyme called phospholipase C cleaves (chops) PIP2 into two fragments, DAG and IP3

• IP3 - diffuses into the cytoplasm and can bind to ligand-gated calcium channels in the endoplasmic reticulum

• Ca2+ is released and binds to proteins

• Response occurs in the cell.

Tags

NGSS.HS-PS1-2

Examine the Signal Transduction pathway and put the events in the correct order.

• Ligand (growth factor) binds to the EGF receptor

• activated receptors trigger a series of events that activate the kinase Raf.

• • Active Raf phosphorylates and activates MEK, which phosphorylates and activates the ERKs.

• ERKs phosphorylate and activate a variety of target molecules.

• Response occurs in the cell.