Genetics of Parkinson's Disease Quiz

What role does genetics play in Parkinson's Disease?

• No role

• Minor role

• Some genetic component

• Complete determinant

What do misfolded α-synuclein proteins form in the brain?

• Plaques

• Tangles

• Lewy bodies

• Prions

What does GWAS stand for?

• Genetic World Analysis Study

• Genome-Wide Association Study

• Gene-Wide Analysis Study

• Genetic-Wide Association Study

Which of the following is NOT typically found in Lewy bodies?

• α-synuclein

• Ubiquitin

• Neurofilament proteins

• Beta-amyloid

What is the role of the E3 ligase Parkin in Parkinson's disease?

• DNA repair

• Protein synthesis

• Degradation and clearance of misfolded α-synuclein

• Lipid metabolism

What protein is encoded by SNCA/PARK1?

• Tau

• Amyloid-beta

• α-synuclein

• Huntingtin

Which of the following is NOT a function of E3 ubiquitin ligase?

• Adding ubiquitin to proteins

• Tagging proteins for degradation

• Synthesizing new proteins

• Working with Pink1 in mitophagy

How does Parkin contribute to the prevention of Parkinson's disease?

• By promoting the formation of Lewy bodies

• By enhancing mitochondrial quality control

• By increasing dopamine production

• By inhibiting synaptic transmission

Which protein is the primary component of Lewy bodies?

• α-synuclein

• Beta-amyloid

• Tau

• Huntingtin

How does PINK1 contribute to the process of mitophagy?

• By phosphorylating ubiquitin and Parkin

• By degrading damaged mitochondria directly

• By increasing ATP production

• By inhibiting mitochondrial fission