Hypersensitivities

What is the immune mechanism behind type 1 diabetes mellitus in terms of hypersensitivity classification?

• Type I hypersensitivity

• Type II hypersensitivity

• Type III hypersensitivity

• Type IV hypersensitivity

What type of hypersensitivity is involved in Myasthenia Gravis, where antibodies block acetylcholine receptors?

• Type I hypersensitivity

• Type II hypersensitivity

• Type III hypersensitivity

• Type IV hypersensitivity

Which immune complexes are primarily responsible for the tissue damage observed in Type III hypersensitivity?

• IgA-antigen complexes

• IgE-antigen complexes

• IgG-antigen complexes

• IgM-antigen complexes

Which cytokine is primarily responsible for the differentiation of B cells into IgE-secreting plasma cells in Type I hypersensitivity?

• IL-4

• IL-5

• IL-12

• IFN-y

In what type of hypersensitivity do antibodies bind directly to cell surfaces, leading to cell lysis or dysfunction, as seen in autoimmune hemolytic anemia?

• Type I hypersensitivity

• Type II hypersensitivity

• Type III hypersensitivity

• Type IV hypersensitivity

What type of hypersensitivity reaction is seen in conditions such as urticaria (hives)?

• Type I

• Type II

• Type III

• Type IV

Multiple sclerosis involves T cell-mediated damage to the myelin sheath of neurons. What type of hypersensitivity is this?

• Type I

• Type II

• Type III

• Type IV

Which of the following mediators is most responsible for the immediate symptoms of a Type I hypersensitivity reaction (e.g., bronchoconstriction, vasodilation)?

• TNF-a

• Histamine

• IL-10

• IFN-a

In type I hypersensitivity reaction, Th2 cells secrete what cytokine to recruit eosinophils?

• TGF-B

• IL-2

• IL-4

• IL-5

In Type II hypersensitivity reactions, what is the role of the complement system?

• Opsonization of immune complexes

• Direct cell lysis via MAC formation

• Suppression of T cell activation

• Phagocytosis of IgE bound antigens