Hematology & Blood Banking Exam

Genetic defect of red cells destruction in hemolytic anemia are:

• Myeloproliferative disorder, CLL, AML

• Red cell membrane defect, Enzyme Deficiency, Hb defect

• Spleen disorder, liver abnormality, bone marrow disorder

• Erythropoietin deficiency, vitamin B12 and free iron deficiency

Myelodysplasia includes a group of clonal disorders of _______ that lead to bone marrow failure and low blood cell counts.

• Hepatocyte abnormality

• Nervous tissue abnormality

• Reticoendothelial tissue / cells

• Hematopoitic stem cells

JACK2 mutation is most commonly characteristic feature of which type of disease?

• Polycythemia vera

• Primary myelofibrosis

• Essential thrombocythemia

• Non-Hodgkin lymphoma

The major subdivision of lymphomas is into Hodgkin lymphoma and non‐Hodgkin lymphoma and this is based on:

• Presence of Lacunar Cells

• Presence of Popcorn Cells

• Presence of Mummified cells

• Presence of Reed Sternberg cells

The Staging of Hodgkin lymphoma are done by clinical representation along with:

• CBC, Bone marrow finding, Immunophenotyping

• Chromosomal analysis, Karyotyping and gene mutation

• Radiological Scan like X-ray, CT & MRI

• Only on X-ray

Multiple myeloma is a tumour of plasma cells that accumulate in the bone marrow,

• Stem cells

• B lymphocytes

• Plasma cells

• Hemopoietic stem cells

A patient is found to have elevated kappa and lambda serum‐free light chains, but the kappa/lambda ratio is raised from the normal range. Which ONE of the following is the most likely cause of this laboratory finding?

• Non-Hodgkin Lymphoma

• Burkit’s lymphoma

• Lacunar myeloma

• Multiple myeloma

Philadelphia (Ph) chromosome is the definitive diagnosis of:

• CML

• AML

• CLL

• ALL

A patient’s complete blood count shows MCV is lower than 80fl & MCH is lower than 27pg & peripheral smear show abnormal erythroblasts containing numerous iron granules arranged in a ring or collar around the nucleus. What provisional diagnosis can be made by a Hematologist?

• Sidero-blastic anemia

• Thalassemia

• Anemia of chronic disease

• Hemolytic anemia

Burkitt’s cells are found in:

• ALL-L2

• ALL-L3

• AML-M1

• AML- M7