Week 4 Recit.

The Y axis tells us how much ______ is bound to __________.

The X axis tells us the amount of ______ is dissolved in the blood.

Hemoglobin oxygen binding curve: What does the point at ~43 toor and 80% Oxyhemoglobin saturation tell us?

High affinity for oxygen is represented in hemoglobin by the ___ state.

• R

• T

Low affinity for oxygen is represented in hemoglobin by the ___ state.

• R

• T

What are two models that describe the cooperativity of hemoglobin?

Describes the change in allosteric equilibrium relative to how the hemoglobin subunits change state all at the same time, where the overall assembly can only exist in either the T or the R state.

• Concerted model

• Sequential model

Describes the binding of one oxygen molecule to one hemoglobin subunit increases the binding affinity of neighboring sites without inducing a full conversion from T to R state.

• Concerted model

• Sequential model

How many coordination sites does Fe 2+ have?

• 1

• 4

• 6

• 7

What are the binding partners of Fe 2+?