Class #1 Quiz!

Of all Dementia cases, Alzheimer's Disease makes up...

• 20-40%

• 60-80%

• 45-55%

• 10-30%

Where is the mutation that leads to amyloid-beta plaques?

• BACE1

• presinilin

• n-terminus

• alpha secretase

How was the enhanced glutamate release probability at the CAI-CA3 synapse measured?

• Western blot

• Paired-pulse facilitation

• Induced vesicle fusion

• Low frequency stimulation

The bundle of CA3 axons extending toward CA1 neurons is called the...

• Shaffer collateral

• Mossy fibers

• Perforant Path

After protein electrophoresis, which proteins remain at the top?

• Heavier proteins

• Lighter proteins

What happens when we add amyloid beta to a brain slice, then block NMDARs!

• Tau hyperphosphorylation is reduced back to control levels

• mGluRs allow for tau hyperphosphorylation to continue

• Tau hyperphosphorylation increses by ~10%

• No change occurs

What happens when you INCREASE the release probability at a synapse? (select all that apply)

• LTP increases

• LTP decreases

• LTD increases

• LTD increases

What conditions are required in order for an NMDAR to open? (select all that apply)

• Glutamate binds

• Postsynaptic hyperpolarization

• Glycine binds

• Glutamine binds

• Postsynaptic depolarization

A ____________ was used to cancel out the effects of Aβ's increase on glutamate release probability

• Fluorescent antibody

• mGluR blocker

• Low-n oligomer

• Voltage-gated Ca2+ channel blocker

Incubation of hippocampal slices in Aβ led to a(n) ________ in hyperphosphorylated tau.