Therapeutics: Diuretic & fluid: Carbonic anhydrase inhibitors

Where do carbonic anhydrase inhibitors work?

• PCT

• DCT

• LOH

• CD

What is the only CAI?

• Acetazolamide (Diamox)

• not this

Select all of the clinical uses for CAIs

• Edema with diuretic resistance

• acid/base disorders

• glaucoma (topical)

Why do CAIs have limited efficacy with edema?

• because reabsorption also happens in the loop later down the line

• not this

What dosage forms do acetazolamide (Diamox) come in?

• IV

• PO

• Opthalmic

Dosing for edema for acetazolamide

• 250 mg IV/PO QD

• 250 mg IV/PO BID

Select all of the ADRs for acetazolamide (Diamox) (the only CAI)

• metabolic acidosis

• hypokalemia

Which diuretic/s will cause metabolic acidosis?

• Carbonic anhydrase inhibitors

• Loop diuretics

• K sparing diuretics

Which diuretic/s will cause metabolic alkalosis?

• Carbonic anhydrase inhibitors

• Loop diuretics

• K sparing diuretics