Chemokine Receptor Signalling Quiz

What are the two main groups into which chemokine receptors can be divided by function?

• Enzyme coupled receptors and GPCRs

• Enzyme coupled receptors and ion channel receptors

• GPCRs and atypical chemokine receptors

• GPCRs and ion channel receptors

What is the role of detection of signals arriving from outside of the cell usually fulfilled by?

• Specific receptors inside the cell

• Specific receptors on the cell surface

• Specific receptors in the cytoplasm

• Specific receptors in the nucleus

What are the four crucial criteria that have to be met by the functioning of a receptor?

• Specificity, binding affinity, signal transmission, and turning on

• Specificity, binding strength, signal transmission, and turning on

• Specificity, binding affinity, signal reception, and turning off

• Specificity, binding affinity, signal transmission, and turning off

Which family of GPCRs constitutes the majority of transmembrane receptors in humans?

• Family A

• Family B

• Frizzled receptors

• Family C

What is the structure of GPCRs that contains seven regions of approximately 22-24 amino acids?

• Three-transmembrane receptors

• Seven-transmembrane receptors

• Four-transmembrane receptors

• Five-transmembrane receptors

Which family of GPCRs is characterized by a long extracellular N terminus containing a series of cysteine residues?

• Olfactory and gustatory receptors

• Family C

• Family B

• Family A

What is the main function of GPCRs that act as receptors for stimuli that have not yet been identified?

• Orphan receptors

• Desensitization receptors

• Recycling receptors

• Internalization receptors

What are the three major mechanisms that lead to GPCRs activation?

• Ligand binding, conformational change, and G-protein activation/deactivation cycle

• Ligand binding, conformational change, and receptor internalization

• Ligand binding, receptor desensitization, and G-protein activation

• Ligand binding, receptor recycling, and G-protein activation

What is the function of full agonists in GPCR signalling?

• Maximal receptor stimulation

• Reduce the level of basal activity

• Partial receptor stimulation

• No effect on signalling activity

Which proteins are negative regulators of G protein signalling?

• G protein-coupled receptor kinases (GRKs)

• Regulators of G protein signalling (RGS)

• Arrestins

• Receptor-activity modifying proteins (RAMPs)