pathophysiology of chronic myeloid leukemia (CML)

is a common symptom of CML?​ (a)   ​

• Fatigue
• Weight loss
• Bone pain
• Shortness of breath

What is the primary cause of chronic myeloid leukemia (CML)?

•    a) Genetic mutation

    

• b) Exposure to environmental toxins

    

• c) Viral infection

    

• d) Autoimmune dysfunction

Which phase of CML is characterized by the presence of abundant blast cells? (a)  

• Blast phase
•    Chronic phase
•    Accelerated phase
•   Remission phase

Which of the following genetic abnormalities is associated with CML?

  

• a) BCR-ABL fusion gene

    

• b) JAK2 gene mutation

    

• c) FLT3 gene mutation

•    d) NPM1 gene mutation

How does CML differ from other types of leukemia, such as acute lymphoblastic leukemia (ALL)?

•    a) Different genetic mutations

    

• b) Age of onset

    

• c) Involvement of lymph nodes

    

• d) Response to chemotherapy

How does the BCR-ABL fusion gene contribute to the development of CML?

  

• a) Inhibits apoptosis

    

• b) Stimulates uncontrolled proliferation

    

• c) Enhances DNA repair mechanisms

    

• d) Suppresses angiogenesis