Amine Chemistry Quiz

What is the first step in the mechanism of the Mannich reaction?

• Enolization

• Nucleophilic attack of the enol

• Proton transfer

• Nucleophilic addition of the amine

Why are alkyldiazonium salts too reactive to be isolated?

• They readily form stable carbocations

• They spontaneously release nitrogen gas to form carbocations

• They are unstabilized by resonance

• They undergo coupling reactions

Which of the following reagents is used for the reductive amination of an aldehyde?

• NaBH4

• LiAlH4

• NaBH3CN

• BH3

What is the chemical function of the major product of a Hofmann elimination?

• Alkane

• Alkene

• Alkyne

• Amide

What is the key advantage of the Gabriel synthesis for the preparation of amines?

• Rapid reaction kinetics

• Formation of stable carbocations

• High yield of secondary amines

• Avoidance of overalkylation

Which of the following molecules is a secondary amine?

• 3-aminobutan-1-ol

• N,N-dimethylpentan-2-amine

• N-ethyl-N-methylpropan-2-amine

• N-methylcyclohexanamine

Which of the following statement about the reaction between 1-bromopropane and ammonia is incorrect?

• The first step is a nucleophilic substitution

• The reaction specifically gives a primary amine

• The reaction initially gives propan-1-amine

• One of the byproducts is NH4+

Which of the following statements is correct about ethylamine?

• EtNH2 is immiscible with water

• EtNH2 has a higher boiling point than EtOH

• EtNH2 is a good electrophile

• Hydrogen bond formation occurs between H2O and EtNH2

Which of the following statements about the reaction between pentanenitrile and LiAlH4 is correct?

• The reaction is a reduction

• The product is 1-butylamine

• There is no significant change in carbon NMR

• All of the above